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In MASH (metabolic dysfunction-associated steatohepatitis, formerly NASH), semaglutide 2.4 mg showed significant resolution of steatohepatitis in a proportion of patients
Important note: Drugs in this analysis were classified according to their FDA-approved label, not the patients diagnosis or reason for use
The safety endpoints were the incidence of hypoglycemic episodes (including severe hypoglycemia), gastrointestinal events, acute pancreatitis, and thyroid cancer
Research applications include studying the glutathione redox cycle, GSH/GSSG ratio as a marker of oxidative status, NAC comparison assays, and hepatoprotective mechanisms
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